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Bias from removing read duplication in ultra-deep sequencing experiments
Motivation: Identifying subclonal mutations and their implications requires accurate estimation of mutant allele fractions from possibly duplicated sequencing reads. Removing duplicate reads assumes that polymerase chain reaction amplification from library constructions is the primary source. The al...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982159/ https://ncbi.nlm.nih.gov/pubmed/24389657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt771 |
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