Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

In arterial myocytes the Ca(2+) mobilizing messenger NAADP evokes spatially restricted Ca(2+) bursts from a lysosome-related store that are subsequently amplified into global Ca(2+) waves by Ca(2+)-induced Ca(2+)-release from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs). Lysosomes...

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Hlavní autoři: Kinnear, Nicholas P., Wyatt, Christopher N., Clark, Jill H., Calcraft, Peter J., Fleischer, Sidney, Jeyakumar, Loice H., Nixon, Graeme F., Mark Evans, A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982125/
https://ncbi.nlm.nih.gov/pubmed/18191199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2007.11.003
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