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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-induced autophagy. Manipulation of β-catenin expression...

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Bibliografske podrobnosti
Main Authors: Petherick, Katy J, Williams, Ann C, Lane, Jon D, Ordóñez-Morán, Paloma, Huelsken, Joerg, Collard, Tracey J, Smartt, Helena JM, Batson, Jennifer, Malik, Karim, Paraskeva, Chris, Greenhough, Alexander
Format: Artigo
Jezik:Inglês
Izdano: European Molecular Biology Organization 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981178/
https://ncbi.nlm.nih.gov/pubmed/23736261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.123
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