β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

BACKGROUND: Levels of the pro-tumorigenic prostaglandin PGE(2) are increased in colorectal cancer, previously attributed to increased synthesis through COX-2 upregulation and, more recently, to decreased catabolism. The functionally linked genes 15-prostaglandin dehydrogenase (15-PGDH) and the prost...

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Detalhes bibliográficos
Main Authors: Smartt, H J M, Greenhough, A, Ordóñez-Morán, P, Al-Kharusi, M, Collard, T J, Mariadason, J M, Huelsken, J, Williams, A C, Paraskeva, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493768/
https://ncbi.nlm.nih.gov/pubmed/23033009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.430
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