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Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress

It is widely accepted that different forms of stress activate a common target, p53, yet different outcomes are triggered in a stress-specific manner. For example, activation of p53 by genotoxic agents, such as camptothecin (CPT), triggers apoptosis, while non-genotoxic activation of p53 by Nutlin-3...

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Detalhes bibliográficos
Main Authors: Chang, Jonathan, Davis-Dusenbery, Brandi N, Kashima, Risa, Jiang, Xuan, Marathe, Nisha, Sessa, Roberto, Louie, Justin, Gu, Wei, Lagna, Giorgio, Hata, Akiko
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981142/
https://ncbi.nlm.nih.gov/pubmed/24219989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.242
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