Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

Eitemau Tebyg

• Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly
  gan: Aitio, Olli, et al.
  Cyhoeddwyd: (2010)
• Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
  gan: Alexandropoulos, K, et al.
  Cyhoeddwyd: (1995)
• Essential role of c-Abl PxxP motifs and its interactions with Crk and Nck adaptors in cell spreading
  gan: Antoku, Susumu, et al.
  Cyhoeddwyd: (2008)
• Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus Macaques
  gan: Carl, Silke, et al.
  Cyhoeddwyd: (2000)
• Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.
  gan: Cussac, D, et al.
  Cyhoeddwyd: (1994)