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Origins and implications of pluripotent stem cell variability and heterogeneity

Pluripotent stem cells constitute a platform to model disease and developmental processes and can potentially be used in regenerative medicine. However, not all pluripotent cell lines are equal in their capacity to differentiate into desired cell types in vitro. Genetic and epigenetic variations con...

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Detalhes bibliográficos
Main Authors: Cahan, Patrick, Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980962/
https://ncbi.nlm.nih.gov/pubmed/23673969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3584
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