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Combined Histone Deacetylase and Cyclooxygenase Inhibition Achieves Enhanced Antiangiogenic Effects in Lung Cancer Cells
PGE2 is an important pro-angiogenic and pro-proliferative cytokine and the key enzymes modulating its levels, COX-2 and 15-PGDH play important opposing roles in carcinogenesis. Previously we found loss of 15-PGDH expression in lung cancer and its reactivation leads to strong in vivo tumor-suppressiv...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3980866/ https://ncbi.nlm.nih.gov/pubmed/22121107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21846 |
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