Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

The multidrug resistance P-glycoprotein (P-gp), which transports hydrophobic drugs out of cells, is also associated with volume-activated chloride currents. It is not yet clear whether P-gp is a channel itself, or whether it is a channel regulator. Activation of chloride currents by hypotonicity in...

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Bibliographic Details
Main Authors: Hardy, S P, Goodfellow, H R, Valverde, M A, Gill, D R, Sepúlveda, V, Higgins, C F
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC398053/
https://ncbi.nlm.nih.gov/pubmed/7828597
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