Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.
Neuropathogenicity of poliovirus can be attenuated by mutations in the internal ribosomal entry site (IRES) within the 5' nontranslated region of its genome. The Sabin vaccine strains used in prevention of poliomyelitis carry such mutations in their IRES elements. In addition, mutations within the s...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39803/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8637880/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.6.2370 |
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