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Preexisting high frequencies of memory CD8(+) T cells favors rapid memory differentiation and preservation of proliferative potential upon boosting
Memory CD8(+) T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8(+) T cell quantity, but reportedly erodes proliferative potential and protective efficacy. This stu...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979587/ https://ncbi.nlm.nih.gov/pubmed/23890070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.003 |
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