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Preexisting high frequencies of memory CD8(+) T cells favors rapid memory differentiation and preservation of proliferative potential upon boosting

Memory CD8(+) T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8(+) T cell quantity, but reportedly erodes proliferative potential and protective efficacy. This stu...

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Bibliographische Detailangaben
Hauptverfasser: Fraser, Kathryn A., Schenkel, Jason M., Jameson, Stephen C., Vezys, Vaiva, Masopust, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979587/
https://ncbi.nlm.nih.gov/pubmed/23890070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.003
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