Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1

Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1 and BD2 and forms a complex with the positive transcription elongation factor b, which controls phosphorylation of RNA poly...

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Detalhes bibliográficos
Main Authors: Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979416/
https://ncbi.nlm.nih.gov/pubmed/24497639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523019
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