A Two-state Model for the Diffusion of the A(2A) Adenosine Receptor in Hippocampal Neurons: AGONIST-INDUCED SWITCH TO SLOW MOBILITY IS MODIFIED BY SYNAPSE-ASSOCIATED PROTEIN 102 (SAP102)

The A(2A) receptor is a class A/rhodopsin-like G protein-coupled receptor. Coupling to its cognate protein, G(s), occurs via restricted collision coupling and is contingent on the presence of cholesterol. Agonist activation slows diffusion of the A(2A) adenosine receptor in the lipid bilayer. We exp...

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Hlavní autoři: Thurner, Patrick, Gsandtner, Ingrid, Kudlacek, Oliver, Choquet, Daniel, Nanoff, Christian, Freissmuth, Michael, Zezula, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979375/
https://ncbi.nlm.nih.gov/pubmed/24509856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505685
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