A Two-state Model for the Diffusion of the A(2A) Adenosine Receptor in Hippocampal Neurons: AGONIST-INDUCED SWITCH TO SLOW MOBILITY IS MODIFIED BY SYNAPSE-ASSOCIATED PROTEIN 102 (SAP102)

The A(2A) receptor is a class A/rhodopsin-like G protein-coupled receptor. Coupling to its cognate protein, G(s), occurs via restricted collision coupling and is contingent on the presence of cholesterol. Agonist activation slows diffusion of the A(2A) adenosine receptor in the lipid bilayer. We exp...

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Bibliographische Detailangaben
Hauptverfasser: Thurner, Patrick, Gsandtner, Ingrid, Kudlacek, Oliver, Choquet, Daniel, Nanoff, Christian, Freissmuth, Michael, Zezula, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979375/
https://ncbi.nlm.nih.gov/pubmed/24509856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505685
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