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Is there a single pathway for the folding of a polypeptide chain?

We argue that folding of the compact domains of proteins can occur with adequate rapidity in the absence of a unique directed mechanism, provided that native-like local structure dominates the folding process. We further suggest that the evolution of amino acid sequences should favor multiple paths...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Harrison, S C, Durbin, R
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1985
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Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397927/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3858860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.12.4028
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