Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord

Monoacylglycerol lipase (MGL) is a multifunctional serine hydrolase, which terminates anti-nociceptive endocannabinoid signaling and promotes pro-nociceptive prostaglandin signaling. Accordingly, both acute nociception and its sensitization in chronic pain models are prevented by systemic or focal s...

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Main Authors: Horváth, Eszter, Woodhams, Stephen G, Nyilas, Rita, Henstridge, Christopher M, Kano, Masanobu, Sakimura, Kenji, Watanabe, Masahiko, Katona, István
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Special Issue: Neurobiology of Pain
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979158/
https://ncbi.nlm.nih.gov/pubmed/24494682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.12470
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