Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment

INTRODUCTION: Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated protein kinase (MAPK) pathways results in anti-estrogen resistance in vitro, but a biomarker with clinical validity to predict intrinsic resistance has not been identified. In metastatic breast cancer patie...

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Detalhes bibliográficos
Main Authors: Beelen, Karin, Opdam, Mark, Severson, Tesa M, Koornstra, Rutger HT, Vincent, Andrew D, Wesseling, Jelle, Muris, Jettie J, Berns, Els MJJ, Vermorken, Jan B, van Diest, Paul J, Linn, Sabine C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979131/
https://ncbi.nlm.nih.gov/pubmed/24447434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3598
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