PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients

INTRODUCTION: Inhibitors of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway can overcome endocrine resistance in estrogen receptor (ER) α-positive breast cancer, but companion diagnostics indicating PI3K/AKT/mTOR activation and consequently en...

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Detalhes bibliográficos
Main Authors: Beelen, Karin, Opdam, Mark, Severson, Tesa M, Koornstra, Rutger HT, Vincent, Andrew D, Wesseling, Jelle, Muris, Jettie J, Berns, Els MJJ, Vermorken, Jan B, van Diest, Paul J, Linn, Sabine C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978618/
https://ncbi.nlm.nih.gov/pubmed/24467828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3606
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