Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

A novel cDNA, IA-2beta, was isolated from a mouse neonatal brain library. The predicted protein sequence revealed an extracellular domain, a transmembrane region, and an intracellular domain. The intracellular domain is 376 amino acids long and 74% identical to the intracellular domain of IA-2, a ma...

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Détails bibliographiques
Auteurs principaux: Lu, J, Li, Q, Xie, H, Chen, Z J, Borovitskaya, A E, Maclaren, N K, Notkins, A L, Lan, M S
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC39791/
https://ncbi.nlm.nih.gov/pubmed/8637868
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