An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.

BACKGROUND: We sought to identify novel islet-cell autoantigens to better understand the pathogenesis, prediction, and immunotherapy of type 1 diabetes. MATERIALS AND METHODS: Macaque and human islet cDNA libraries expressed in mammalian cells were screened with human diabetes sera. A positive clone...

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Main Authors: LaGasse, J., Jelinek, L., Sexson, S., Lofton-Day, C., Breininger, J., Sheppard, P., Kindsvogel, W., Hagopian, W. A.
Format: Artigo
Sprog:Inglês
Udgivet: The Feinstein Institute for Medical Research 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230046/
https://ncbi.nlm.nih.gov/pubmed/9100223
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