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Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

INTRODUCTION: Methotrexate (MTX) has been for decades a standard treatment in a wide range of conditions, from malignancies to rheumatoid arthritis (RA). Despite this long experience, the mechanisms of action of MTX remain incompletely understood. Reported immunologic effects of MTX include inductio...

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Autors principals: Olsen, Nancy J, Spurlock, Charles F, Aune, Thomas M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978848/
https://ncbi.nlm.nih.gov/pubmed/24444433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4444
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