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Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

INTRODUCTION: Methotrexate (MTX) has been for decades a standard treatment in a wide range of conditions, from malignancies to rheumatoid arthritis (RA). Despite this long experience, the mechanisms of action of MTX remain incompletely understood. Reported immunologic effects of MTX include inductio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Olsen, Nancy J, Spurlock, Charles F, Aune, Thomas M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978848/
https://ncbi.nlm.nih.gov/pubmed/24444433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4444
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