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Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

INTRODUCTION: Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect agains...

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Detalhes bibliográficos
Main Authors: Siebelt, Michiel, Groen, Harald C, Koelewijn, Stuart J, de Blois, Erik, Sandker, Marjan, Waarsing, Jan H, Müller, Cristina, van Osch, Gerjo JVM, de Jong, Marion, Weinans, Harrie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978821/
https://ncbi.nlm.nih.gov/pubmed/24472689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4461
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