Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

INTRODUCTION: Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect agains...

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Main Authors: Siebelt, Michiel, Groen, Harald C, Koelewijn, Stuart J, de Blois, Erik, Sandker, Marjan, Waarsing, Jan H, Müller, Cristina, van Osch, Gerjo JVM, de Jong, Marion, Weinans, Harrie
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978821/
https://ncbi.nlm.nih.gov/pubmed/24472689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4461
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