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Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration

INTRODUCTION: The Rho GTPase Cdc42 is overexpressed and hyperactivated in breast tumors compared to normal breast tissue. Cdc42 regulates key processes that are critical for mammary gland morphogenesis and become disrupted during the development, progression, and metastasis of breast cancer. However...

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Detalhes bibliográficos
Main Authors: Bray, Kristi, Gillette, Melissa, Young, Jeanette, Loughran, Elizabeth, Hwang, Melissa, Sears, James Cooper, Vargo-Gogola, Tracy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978759/
https://ncbi.nlm.nih.gov/pubmed/24074261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3487
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