A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes()

The glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia disrupts cell function and contributes to many pathologies, including those associated with diabetes and aging. Intracellular glycation occurs after the generation of the reactive 1,2-dicarbonyls methylglyoxal a...

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Autori principali: Pun, Pamela Boon Li, Logan, Angela, Darley-Usmar, Victor, Chacko, Balu, Johnson, Michelle S., Huang, Guang W., Rogatti, Sebastian, Prime, Tracy A., Methner, Carmen, Krieg, Thomas, Fearnley, Ian M., Larsen, Lesley, Larsen, David S., Menger, Katja E., Collins, Yvonne, James, Andrew M., Kumar, G.D. Kishore, Hartley, Richard C., Smith, Robin A.J., Murphy, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2014
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Original Contribution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978666/
https://ncbi.nlm.nih.gov/pubmed/24316194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.11.025
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