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Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators()
Soluble Guanylate Cyclase (sGC) is the receptor for the signalling agent nitric oxide (NO) and catalyses the production of the second messenger cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). The enzyme is an attractive drug target for small molecules that act in the cardiov...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier Science Ltd
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3978654/ https://ncbi.nlm.nih.gov/pubmed/24480469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.015 |
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