Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain

INTRODUCTION: Nerve growth factor (NGF) level is increased in osteoarthritis (OA) joints and is involved in pain associated with OA. Stimuli responsible for NGF stimulation in chondrocytes are unknown. We investigated whether mechanical stress and proinflammatory cytokines may influence NGF synthesi...

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Main Authors: Pecchi, Emilie, Priam, Sabrina, Gosset, Marjolaine, Pigenet, Audrey, Sudre, Laure, Laiguillon, Marie-Charlotte, Berenbaum, Francis, Houard, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978639/
https://ncbi.nlm.nih.gov/pubmed/24438745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4443
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