Interferon alpha inhibits antigen-specific production of proinflammatory cytokines and enhances antigen-specific transforming growth factor beta production in antigen-induced arthritis

INTRODUCTION: Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered arthritis. To understand this tolerogenic mechanism, we...

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Main Authors: Chalise, Jaya Prakash, Narendra, Sudeep Chenna, Paudyal, Bhesh Raj, Magnusson, Mattias
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978460/
https://ncbi.nlm.nih.gov/pubmed/24286140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4326
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