EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca(++), and Erk, leading to granule polarization

Ewing’s sarcoma-associated transcript 2 (EAT-2) is an Src homology 2 domain-containing intracellular adaptor related to signaling lymphocytic activation molecule (SLAM)–associated protein (SAP), the X-linked lymphoproliferative gene product. Both EAT-2 and SAP are expressed in natural killer (NK) ce...

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Main Authors: Pérez-Quintero, Luis-Alberto, Roncagalli, Romain, Guo, Huaijian, Latour, Sylvain, Davidson, Dominique, Veillette, André
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978279/
https://ncbi.nlm.nih.gov/pubmed/24687958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132038
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