T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice

T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is highly up-regulated in the injured mouse brain afte...

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Bibliografiska uppgifter
Huvudupphovsmän: Clarkson, Benjamin D.S., Ling, Changying, Shi, Yejie, Harris, Melissa G., Rayasam, Aditya, Sun, Dandan, Salamat, M. Shahriar, Kuchroo, Vijay, Lambris, John D., Sandor, Matyas, Fabry, Zsuzsanna
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2014
Ämnen:
Brief Definitive Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978271/
https://ncbi.nlm.nih.gov/pubmed/24616379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131377
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