Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor

Deregulation of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-70 kDa ribosomal protein S6 kinase 1 (p70(S6K)) pathway is commonly observed in many tumors. This pathway controls proliferation, survival, and translation, and its overactivation is associated with poo...

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Autori principali: Bajer, Magdalena M., Kunze, Michael M., Blees, Johanna S., Bokesch, Heidi R., Chen, Hanyong, Brauß, Thilo F., Dong, Zigang, Gustafson, Kirk R., Biondi, Ricardo M., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias, Brüne, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978168/
https://ncbi.nlm.nih.gov/pubmed/24513322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.01.034
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