Lactaptin Induces p53-Independent Cell Death Associated with Features of Apoptosis and Autophagy and Delays Growth of Breast Cancer Cells in Mouse Xenografts

Lactaptin, the proteolytic fragment of human milk kappa-casein, induces the death of various cultured cancer cells. The mechanisms leading to cell death after lactaptin treatment have not been well characterized. In this study the in vivo and in vitro effects of a recombinant analogue of lactaptin (...

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Detalhes bibliográficos
Main Authors: Koval, Olga A., Tkachenko, Anastasiya V., Fomin, Alexandr S., Semenov, Dmitry V., Nushtaeva, Anna A., Kuligina, Elena V., Zavjalov, Eugeny L., Richter, Vladimir A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978064/
https://ncbi.nlm.nih.gov/pubmed/24710119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093921
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