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A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.

The coding region for the major polypeptide (p24S) of hepatitis B surface antigen (HBsAg) is preceded by an in-phase open reading frame termed pre-S. The coding potential of the pre-S region was examined in mouse L cells transformed with cloned hepatitis B virus DNA. Such cells produce three HBsAg-r...

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Bibliografski detalji
Glavni autori: Persing, D H, Varmus, H E, Ganem, D
Format: Artigo
Jezik:Inglês
Izdano: 1985
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC397791/
https://ncbi.nlm.nih.gov/pubmed/3858831
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