Dysregulated Gene Expression in the Primary Osteoblasts and Osteocytes Isolated from Hypophosphatemic Hyp Mice

Osteocytes express multiple genes involved in mineral metabolism including PHEX, FGF23, DMP1 and FAM20C. In Hyp mice, a murine model for X-linked hypophosphatemia (XLH), Phex deficiency results in the overproduction of FGF23 in osteocytes, which leads to hypophosphatemia and impaired vitamin D metab...

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Detalhes bibliográficos
Main Authors: Miyagawa, Kazuaki, Yamazaki, Miwa, Kawai, Masanobu, Nishino, Jin, Koshimizu, Takao, Ohata, Yasuhisa, Tachikawa, Kanako, Mikuni-Takagaki, Yuko, Kogo, Mikihiko, Ozono, Keiichi, Michigami, Toshimi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977859/
https://ncbi.nlm.nih.gov/pubmed/24710520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093840
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