A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Cross-species transmission of zoonotic coronaviruses (CoVs) can result in pandemic disease outbreaks. Middle East respiratory syndrome CoV (MERS-CoV), identified in 2012, has caused 182 cases to date, with ~43% mortality, and no small animal model has been reported. MERS-CoV and Pipistrellus bat cor...

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Autors principals: Agnihothram, Sudhakar, Yount, Boyd L., Donaldson, Eric F., Huynh, Jeremy, Menachery, Vineet D., Gralinski, Lisa E., Graham, Rachel L., Becker, Michelle M., Tomar, Sakshi, Scobey, Trevor D., Osswald, Heather L., Whitmore, Alan, Gopal, Robin, Ghosh, Arun K., Mesecar, Andrew, Zambon, Maria, Heise, Mark, Denison, Mark R., Baric, Ralph S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977350/
https://ncbi.nlm.nih.gov/pubmed/24667706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00047-14
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