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Protein Disulfide Isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association

The response to endoplasmic reticulum (ER) stress relies on activation of unfolded protein response (UPR) sensors, and the outcome of the UPR depends on the duration and strength of signal. Here we demonstrate a novel mechanism that attenuates the activity of the UPR sensor inositol-requiring enzyme...

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Autores principales: Eletto, Davide, Eletto, Daniela, Dersh, Devin, Gidalevitz, Tali, Argon, Yair
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977204/
https://ncbi.nlm.nih.gov/pubmed/24508390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.004
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