11ß-Hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline

Excess cortisol levels are linked with brain atrophy and cognitive decline in older people. 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) potently amplifies intracellular glucocorticoid action by converting inert cortisone to active cortisol, but any causal importance in brain ageing is unexplo...

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Autori principali: MacLullich, Alasdair MJ, Ferguson, Karen J, Reid, Louise M, Deary, Ian J, Starr, John M, Wardlaw, Joanna M, Walker, Brian R, Andrew, Ruth, Seckl, Jonathan R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977035/
https://ncbi.nlm.nih.gov/pubmed/20961667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.09.010
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