Visualization of Distinct Substrate Recruitment Pathways in the Yeast Exosome by Electron Microscopy

The eukaryotic exosome is a multi-subunit complex typically composed of a catalytically inactive core and the Rrp44 protein, which contains 3’ to 5’ exo- and endo-ribonuclease activities. RNA substrates have been shown to be recruited through the core to reach Rrp44's exoribonuclease (EXO) site...

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Bibliographic Details
Main Authors: Liu, Jun-Jie, Bratkowski, Matthew A., Liu, Xueqi, Niu, Chu-Ya, Ke, Ailong, Wang, Hong-Wei
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976988/
https://ncbi.nlm.nih.gov/pubmed/24336220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2736
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