Fragile Histidine Triad (FHIT) Suppresses Proliferation and Promotes Apoptosis in Cholangiocarcinoma Cells by Blocking PI3K-Akt Pathway

Fragile histidine triad (FHIT) is a tumor suppressor protein that regulates cancer cell proliferation and apoptosis. However, its exact mechanism of action is poorly understood. Phosphatidylinositol 3-OH kinase (PI3K)-Akt-survivin is an important signaling pathway that was regulated by FHIT in lung...

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Autori principali: Huang, Qiang, Liu, Zhen, Xie, Fang, Liu, Chenhai, Shao, Feng, Zhu, Cheng-lin, Hu, Sanyuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976809/
https://ncbi.nlm.nih.gov/pubmed/24757411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/179698
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