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Mutations in the phosphoglucose isomerase gene can lead to marked alterations in cellular ATP levels in cultured fibroblasts exposed to simple nutrient shifts.

The generation of ATP in a hamster fibroblast mutant devoid of the enzyme phosphoglucose isomerase (PGI) has been studied and compared with that in the parental line, which is PGI+. Both cell lines could be maintained for 24 hr in hexose media devoid of L-glutamine. Under these conditions in mannose...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Plesner, P, Ullrey, D B, Kalckar, H M
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1985
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397645/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3857613/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.9.2761
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