Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy

Mitochondrial complex I, the primary entry point for electrons into the mitochondrial respiratory chain, is both critical for aerobic respiration and a major source of reactive oxygen species. In the heart, chronic dysfunction driving cardiomyopathy is frequently associated with decreased complex I...

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Main Authors: Chouchani, Edward T., Methner, Carmen, Buonincontri, Guido, Hu, Chou-Hui, Logan, Angela, Sawiak, Stephen J., Murphy, Michael P., Krieg, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976382/
https://ncbi.nlm.nih.gov/pubmed/24705922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094157
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