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The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function
TMEM127 is an endosome-associated tumor suppressor gene in pheochromocytomas, neuroendocrine tumors that can co-occur with renal cell carcinomas (RCCs). TMEM127 loss leads to increased mTOR signaling. However, the spectrum of tumors with TMEM127 mutation and how TMEM127 and mTOR interact in tumorige...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976335/ https://ncbi.nlm.nih.gov/pubmed/24334765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt638 |
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