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Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation
Aberrant activation of transglutaminase 2 (TGase2) contributes to a variety of protein conformational disorders such as neurodegenerative diseases and age-related cataracts. The accumulation of improperly folded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR),...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976127/ https://ncbi.nlm.nih.gov/pubmed/24481335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2014.1640 |
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