Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue

Human butyrylcholinesterase (BChE) is considered a candidate bioscavenger of nerve agents for use in pre- and post-exposure treatment. The presence and functional necessity of complex N-glycans (i.e. sialylated structures) is a challenging issue in respect to its recombinant expression. We aim to pr...

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Bibliografiske detaljer
Main Authors: Schneider, Jeannine D., Castilho, Alexandra, Neumann, Laura, Altmann, Friedrich, Loos, Andreas, Kannan, Latha, Mor, Tsafrir S., Steinkellner, Herta
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975692/
https://ncbi.nlm.nih.gov/pubmed/24130173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300229
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