Reconstructing complex regions of genomes using long-read sequencing technology

Obtaining high-quality sequence continuity of complex regions of recent segmental duplication remains one of the major challenges of finishing genome assemblies. In the human and mouse genomes, this was achieved by targeting large-insert clones using costly and laborious capillary-based sequencing a...

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Autors principals: Huddleston, John, Ranade, Swati, Malig, Maika, Antonacci, Francesca, Chaisson, Mark, Hon, Lawrence, Sudmant, Peter H., Graves, Tina A., Alkan, Can, Dennis, Megan Y., Wilson, Richard K., Turner, Stephen W., Korlach, Jonas, Eichler, Evan E.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975067/
https://ncbi.nlm.nih.gov/pubmed/24418700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.168450.113
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