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ADP Ribosylation Factor 6 (Arf6) Acts through FilGAP Protein to Down-regulate Rac Protein and Regulates Plasma Membrane Blebbing

The small GTP-binding protein Arf6 reorganizes the actin cytoskeleton through the regulation of Rac activity. We identified FilGAP, a Rac-specific Rho GTPase-activating protein that is recruited to plasma membranes by binding to activated Arf6. FilGAP binds to Arf6 through its pleckstrin homology do...

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Detalhes bibliográficos
Main Authors: Kawaguchi, Kaori, Saito, Koji, Asami, Hisayo, Ohta, Yasutaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975016/
https://ncbi.nlm.nih.gov/pubmed/24526684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546051
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