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The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer’s disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosophila expressing the amyloid beta peptide (Aβ). We fi...

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Detalhes bibliográficos
Main Authors: Chen, Ko-Fan, Possidente, Bernard, Lomas, David A., Crowther, Damian C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974455/
https://ncbi.nlm.nih.gov/pubmed/24574361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014134
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