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Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity
The mechanisms governing positive selection of T cells in the thymus are still incompletely understood. Here, we describe a N-ethyl-N-nitrosourea induced recessive mouse mutant, Ms. T-less, which lacks T cells in the peripheral blood because of a complete block of thymocyte development at the CD4(+)...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC397439/ https://ncbi.nlm.nih.gov/pubmed/15064401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306907101 |
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