Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity

The mechanisms governing positive selection of T cells in the thymus are still incompletely understood. Here, we describe a N-ethyl-N-nitrosourea induced recessive mouse mutant, Ms. T-less, which lacks T cells in the peripheral blood because of a complete block of thymocyte development at the CD4(+)...

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Bibliografske podrobnosti
Main Authors: Wen, Ben G., Pletcher, Mathew T., Warashina, Masaki, Choe, Sun Hui, Ziaee, Niusha, Wiltshire, Tim, Sauer, Karsten, Cooke, Michael P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC397439/
https://ncbi.nlm.nih.gov/pubmed/15064401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306907101
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