Enantioselective syntheses and biological studies of aeruginosin 298-A and its analogs: Application of catalytic asymmetric phase-transfer reaction

Aeruginosin 298-A was isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-298) and is an equipotent thrombin and trypsin inhibitor. A variety of analogs were synthesized to gain insight into the structure–activity relations. We developed a versatile synthetic process for aerugin...

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Main Authors: Fukuta, Yuhei, Ohshima, Takashi, Gnanadesikan, Vijay, Shibuguchi, Tomoyuki, Nemoto, Tetsuhiro, Kisugi, Takaya, Okino, Tatsufumi, Shibasaki, Masakatsu
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Asymmetric Catalysis Special Feature Part I
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC397400/
https://ncbi.nlm.nih.gov/pubmed/15004282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307154101
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